NAD⁺ restores memory in Alzheimer’s disease models by correcting RNA errors
Alzheimer’s disease (AD), the leading cause of dementia, affects nearly 40 million individuals globally. Despite extensive research over the past decades, no treatments have been found that can halt or reverse the progression of this devastating disease. In AD, a major contributor to neuronal dysfunction is the protein tau. An international team of researchers has reported a new mechanism by which boosting the natural metabolite NAD⁺ can protect the brain from the degeneration associated with AD. NAD⁺ (nicotinamide adenine dinucleotide, oxidized form) is a vital metabolite involved in energy metabolism and neuronal resilience in the body. It normally declines with.